Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 58, Issue -, Pages 43-52Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2019.05.018
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Funding
- EPSRC
- Academy of Medical Sciences
- Wellcome Trust
- Royal Society
- EPSRC [EP/R011818/1] Funding Source: UKRI
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The molecular machinery of life is largely created via self-organisation of individual molecules into functional assemblies. Minimal coarse-grained models, in which a whole macromolecule is represented by a small number of particles, can be of great value in identifying the main driving forces behind self-organisation in cell biology. Such models can incorporate data from both molecular and continuum scales, and their results can be directly compared to experiments. Here we review the state of the art of models for studying the formation and biological function of macromolecular assemblies in living organisms. We outline the key ingredients of each model and their main findings. We illustrate the contribution of this class of simulations to identifying the physical mechanisms behind life and diseases, and discuss their future developments.
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