Journal
CURRENT OPINION IN NEUROBIOLOGY
Volume 58, Issue -, Pages 175-180Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2019.09.008
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Funding
- N.I.H. [R01 MH102365, R01 EY022951, R01 MH113852]
- SFARI Research Grant from the Simons Foundation
- McKnight Fellowship
- Ludwig Family Foundation
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Cortical networks receive a highly variable stream of inputs from internal and external influences, and must flexibly adapt their operations on a short timescale. Recent work has highlighted this state-dependent functional flexibility of cortical circuits and provided initial insights into underlying circuit-level mechanisms. Transitions from quiescent to aroused or task-engaged behavioral states are associated with common motifs of network activity, including changes in correlations and enhanced sensory encoding. Evidence points to a key role for selective activation of specific GABAergic interneuron populations in mediating mode-switching in cortical networks. Finally, inhibitory interneurons may function as a critical target for convergent state-dependent neuromodulatory sculpting of cortical circuits.
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