Journal
CURRENT OPINION IN CHEMICAL BIOLOGY
Volume 52, Issue -, Pages 112-124Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2019.06.006
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Funding
- NCCR Chemical Biology
- Swiss National Science Foundation
- ERC
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Peptide nucleic acid (PNA) stands as one of the most successful artificial oligonucleotide mimetics. Salient features include the stability of hybridization complexes (either as duplexes or triplexes), metabolic stability, and ease of chemical modifications. These features have enabled important applications such as antisense agents, gene editing, nucleic acid sensing and as a platform to program the assembly of PNA-tagged molecules. Here, we review recent advances in these areas.
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