Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 60, Issue -, Pages 27-35Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2019.03.008
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Funding
- Howard Hughes Medical Institute [F31 GM122339, 5T32GM007231-44, NIGMS/NIHR01GM112008, R35GM127075]
- David and Lucile Packard Foundation
- Johns Hopkins University startup funds
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The asymmetric division of adult stem cells into one self-renewing stem cell and one differentiating cell is critical for maintaining homeostasis in many tissues. One paradigmatic model of this division is the Drosophila male and female germline stem cell, which provides two model systems not only sharing common features but also having distinct characteristics for studying asymmetric stem cell division in vivo. This asymmetric division is controlled by a combination of extrinsic signaling molecules and intrinsic factors that are either asymmetrically segregated or regulated differentially following division. In this review, we will discuss recent advances in understanding the molecular and cellular mechanisms guiding this asymmetric outcome, including extrinsic cues, intrinsic factors governing cell fate specification, and cell cycle control.
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