Journal
CURRENT MEDICINAL CHEMISTRY
Volume 26, Issue 24, Pages 4681-4696Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/0929867326666190614123835
Keywords
Solid lipid nanoparticles; nanostructurcd lipid carriers; active natural compounds; drug delivery; stability; carrier systems
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Phytochemicals represent an important class of bioactive compounds characterized by significant health benefits. Notwithstanding these important features, their potential therapeutic properties suffer from poor water solubility and membrane permeability limiting their approach to nutraceutical and pharmaceutical applications. Lipid nanoparticles are well known carrier systems endowed with high biodegradation and an extraordinary biocompatible chemical nature, successfully used as platform for advanced delivery of many active compounds, including the oral, topical and systemic routes. This article is aimed at reviewing the last ten years of studies about the application of lipid nanoparticles in active natural compounds reporting examples and advantages of these colloidal carrier systems.
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