Journal
BIOLOGICAL PSYCHOLOGY
Volume 116, Issue -, Pages 23-27Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.biopsycho.2015.11.017
Keywords
Deviance detection; Middle latency response; Animal models; Stimulus-specific adaptation; Mismatch negativity
Funding
- ICREA Academia Distinguished Professorship
- ERC
- Israel Science Foundation
- [PSI2012-37174]
- [SGR2014-177]
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Detecting unexpected stimuli in the environment is a critical function of the auditory system. Responses to unexpected deviant sounds are enhanced compared to responses to expected stimuli. At the human scalp, deviance detection is reflected in the mismatch negativity (MMN) and in an enhancement of the middle-latency response (MLR). Single neurons often respond more strongly to a stimulus when rare than when common, a phenomenon termed stimulus-specific adaptation (SSA). Here we compare stimulus specific adaptation with scalp-recorded deviance-related responses. We conclude that early markers of deviance detection in the time range of the MLR could be a direct correlate of cortical SSA. Both occur at an early level of cortical activation, both are robust findings with low-probability stimuli, and both show properties of genuine deviance detection. Their causal relation with the later scalp-recorded MMN is a key question in this field. (C) 2015 Elsevier B.V. All rights reserved.
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