Changes in Cannabis Potency Over the Last 2 Decades (1995-2014): Analysis of Current Data in the United States

BACKGROUND: Marijuana is the most widely used illicit drug in the United States and all over the world. Reports indicate that the potency of cannabis preparation has been increasing. This report examines the concentration of cannabinoids in illicit cannabis products seized by the U.S. Drug Enforcement Administration over the last 2 decades, with particular emphasis on Delta(9)-tetrahydrocannabinol and cannabidiol. METHODS: Samples in this report were received over time from materials confiscated by the Drug Enforcement Administration and processed for analysis using a validated gas chromatography with flame ionization detector method. RESULTS: Between January 1, 1995, and December 31, 2014, 38,681 samples of cannabis preparations were received and analyzed. The data showed that although the number of marijuana samples seized over the last 4 years has declined, the number of sinsemilla samples has increased. Overall, the potency of illicit cannabis plant material has consistently increased over time since 1995 from similar to 4% in 1995 to similar to 12% in 2014. The cannabidiol content has decreased on average from similar to.28% in 2001 to, <.15% in 2014, resulting in a change in the ratio of Delta(9)-tetrahydrocannabinol to cannabidiol from 14 times in 1995 to similar to 80 times in 2014. CONCLUSIONS: There is a shift in the production of illicit cannabis plant material from regular marijuana to sinsemilla. This increase in potency poses higher risk of cannabis use, particularly among adolescents.