Journal
BIOLOGICAL PSYCHIATRY
Volume 79, Issue 3, Pages 155-164Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2015.04.013
Keywords
Axonal release; Evolution; Ontogenesis; Oxytocin; Oxytocin receptor; Social behavior; Somatodendritic release
Categories
Funding
- Chica and Heinz Schaller Research Foundation
- German Research Foundation [GR 3619/4-1]
- German Research Foundation within the Collaborative Research Center Functional Ensembles [SFB-1134]
- Royal Society Edinburgh Award
- Partenariat Hubert Curien PROCOPE program (German Academic Exchange Service and Campus France)
- Human Frontiers Research Program [RGP0019/2015]
- Telethon Foundation [GGP12207]
- National Council of Research Project on Aging and Regione Lombardia [118099/RCC]
- Ministero della Salute [RF2010-2311148]
- German Academic Exchange Service program for partnership between German and Japanese Universities
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Oxytocin (OT) is a neuropeptide, which can be seen to be one of the molecules of the decade due to its profound prosocial effects in nonvertebrate and vertebrate species, including humans. Although OT can be detected in various physiological fluids (blood, saliva, urine, cerebrospinal fluid) and brain tissue, it is unclear whether peripheral and central OT releases match and synergize. Moreover, the pathways of OT delivery to brain regions involved in specific behaviors are far from clear. Here, we discuss the evolutionarily and ontogenetically determined pathways of OT delivery and OT signaling, which orchestrate activity of the mesolimbic social decision-making network. Furthermore, we speculate that both the alteration in OT delivery and OT receptor expression may cause behavioral abnormalities in patients afflicted with psychosocial diseases.
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