Journal
CLINICAL INFECTIOUS DISEASES
Volume 69, Issue -, Pages 519-520Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cid/ciz823
Keywords
cefiderocol; cephalosporin; carbapenem-resistant Enterobacteriaceae; nonfermenting gram-negative bacteria; siderophore
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Funding
- Shionogi & Co, Ltd (Osaka, Japan)
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Cefiderocol, a novel siderophore cephalosporin in late-stage clinical development, utilizes a Trojan horse active transport mechanism to enter bacteria and has proven in vitro activity against carbapenem-resistant gram-negative pathogens, including those with major carbapenem-resistance mechanisms, and stability against all carbapenemases.
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