Journal
CLINICAL IMMUNOLOGY
Volume 207, Issue -, Pages 1-9Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2019.06.009
Keywords
Systemic lupus erythematosus; Macrophage activation; Apoptosis; Phagocytosis; Type I interferon
Categories
Funding
- Shandong Natural Science Foundation [ZR2013HM068]
- National Natural Science Foundation of China [31370897, 81671605]
- Key Research and Development Plan of Shandong Province [2018GSF118113]
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As a heterogeneous autoimmune disease associated with severe organ damage, the precise mechanisms of systemic lupus erythematosus (SLE) remain to be clarified. Recent research indicates that innate immunity plays vital roles in SLE. Defects in the phagocytosis of apoptotic cells, aberrant activation and imbalanced polarization of macrophages, have been shown to participate in the pathogenesis of SLE. Treatments targeting these processes may ameliorate the disease activity in lupus models as well as in patients with SLE. Macrophages participate in the initiation of autoimmunity and the development of SLE in multiple levels. Better understanding of this complex disease is the prerequisite for exploring more effective therapies of SLE.
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