Journal
CLINICAL AND EXPERIMENTAL MEDICINE
Volume 20, Issue 1, Pages 1-9Publisher
SPRINGER-VERLAG ITALIA SRL
DOI: 10.1007/s10238-019-00592-5
Keywords
Iron overload; Iron chelation therapy; Myelodysplastic syndrome; Overall survival; Leukemia-free survival
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Funding
- Shaanxi International Scientific Research Cooperation and Exchange Program [2016KW-020]
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Iron overload remains a concern in myelodysplastic syndrome (MDS) patients especially those requiring recurrent blood transfusions. Whether iron chelating therapy (ICT) is beneficial to the long-term survival of myelodysplastic syndrome is still a controversial issue. Therefore, we conducted a systematic review and meta-analysis to clarify the relationship between ICT and long-term survival in patients with MDS. A total of 14 studies involving 7242 participants were identified; the outcomes revealed that for patients with MDS, ICT resulted in a lower risk of mortality compared to those with no ICT (HR 0.57; 95% CI 0.44-0.70; P < 0.001); what is more, ICT led to a lower risk of leukemia transformation (HR 0.70; 95% CI 0.52-0.93; P = 0.016). Results of subgroup analyses based on adequate ICT or any ICT, low/int-1 IPSS or unclassified IPSS and study types indicated that the ICT had a beneficial role in all these groups of patients.
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