Journal
CHIRALITY
Volume 32, Issue 1, Pages 81-97Publisher
WILEY
DOI: 10.1002/chir.23142
Keywords
benzophenone; chiral derivative of xanthone; chiral recognition; chiral stationary phase; docking; enantioselectivity; liquid chromatography
Funding
- European Regional Development Fund [PTDC/MAR-BIO/4694/2014]
- Fundacao para a Ciencia e a Tecnologia [FCT UID/QUI/00062/2019, UID/Multi/04423/2019, CHIRALBIOACTIVE-PI-3RL-IINFACTS-2019]
- Fundação para a Ciência e a Tecnologia [PTDC/MAR-BIO/4694/2014] Funding Source: FCT
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Recently, we reported the development of new chiral stationary phases (CSPs) for liquid chromatography (LC) based on chiral derivatives of xanthones (CDXs). Based on the most promising CDX selectors, 12 new CSPs were successfully prepared starting from suitable functionalized small molecules including xanthone and benzophenone derivatives. The chiral selectors comprising one, two, three, or four chiral moieties were covalently bonded to a chromatographic support and further packed into LC stainless-steel columns (150 x 2.1 mm I.D.). The enantioselective performance of the new CSPs was evaluated by LC using different classes of chiral compounds. Specificity for enantioseparation of some CDXs was observed in the evaluation of the new CSPs. Besides, assessment of chiral recognition mechanisms was performed by computational studies using molecular docking approach, which are in accordance with the chromatographic parameters. X-Ray analysis was used to establish a chiral selector 3D structure.
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