Journal
CHEMMEDCHEM
Volume 15, Issue 1, Pages 13-16Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cmdc.201900546
Keywords
magnesium; MOF; bone protection; anti-inflammation; osteoarthritis
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Funding
- National Foundation of Science and Technology of China [11872200, 21607102, 21704039]
- Guangdong Foundation of Science and Technology [2017B030301018]
- Shenzhen Science and Technology Innovation Committee [JCYJ20170817111312887, ZDSYS20140509142721429]
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This study was designed to explore the potential therapeutic effects of Mg-based metal organic frameworks (MOFs) in osteoarthritis (OA) and to broaden the application field of MOFs. Mg/HCOOH-MOF was introduced and characterized by using SEM, XRD, TGA, and FTIR. ICP-MS results proved that Mg/HCOOH-MOF is stable in various physiological media and can maintain the release of Mg2+ ions for a long time. In vitro experiments were carried out to evaluate its potential application in attenuating OA. Mg/HCOOH-MOF was successfully synthesized, and results of MTT assays showed that it is biocompatible and can promote cell proliferation. qPCR results suggested that it can significantly regulate the expression of OCN, Axin2, iNOS and IL-1 beta, which indicated its activity in anti-inflammation and bone protection. We believe that Mg/HCOOH-MOF could benefit OA therapy.
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