Related references
Note: Only part of the references are listed.Design of Highly Potent, Dual-Acting and Central-Nervous-System-Penetrating HIV-1 Protease Inhibitors with Excellent Potency against Multidrug-Resistant HIV-1 Variants
Arun K. Ghosh et al.
CHEMMEDCHEM (2018)
Multi-spectroscopic and molecular modeling approaches to elucidate the binding interaction between bovine serum albumin and darunavir, a HIV protease inhibitor
Jie-Hua Shi et al.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2018)
Sub-picomolar Inhibition of HIV-1 Protease with a Boronic Acid
Ian W. Windsor et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)
Design and Development of Highly Potent HIV-1 Protease Inhibitors with a Crown-Like Oxotricyclic Core as the P2-Ligand To Combat Multidrug-Resistant HIV Variants
Arun K. Ghosh et al.
JOURNAL OF MEDICINAL CHEMISTRY (2017)
A novel central nervous system-penetrating protease inhibitor overcomes human immunodeficiency virus 1 resistance with unprecedented aM to pM potency
Manabu Aoki et al.
ELIFE (2017)
Design, Synthesis, Biological Evaluation, and X-ray Studies of HIV-1 Protease Inhibitors with Modified P2 Ligands of Darunavir
Arun K. Ghosh et al.
CHEMMEDCHEM (2017)
Recent Progress in the Development of HIV-1 Protease Inhibitors for the Treatment of HIV/AIDS
Arun K. Ghosh et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Dimerization of HIV-1 protease occurs through two steps relating to the mechanism of protease dimerization inhibition by darunavir
Hironori Hayashi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
P2' Benzene Carboxylic Acid Moiety Is Associated with Decrease in Cellular Uptake: Evaluation of Novel Nonpeptidic HIV-1 Protease Inhibitors Containing P2 bis-Tetrahydrofuran Moiety
Ravikiran S. Yedidi et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2013)
JLigand: a graphical tool for the CCP4 template-restraint library
Andrey A. Lebedev et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2012)
Enhancing Protein Backbone BindinguA Fruitful Concept for Combating Drug-Resistant HIV
Arun K. Ghosh et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2012)
Genotypic resistance profiles associated with virological failure to darunavir-containing regimens: a cross-sectional analysis
G. Sterrantino et al.
INFECTION (2012)
Overview of the CCP4 suite and current developments
Martyn D. Winn et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2011)
Design of HIV-1 Protease Inhibitors with C3-Substituted Hexahydrocyclopentafuranyl Urethanes as P2-Ligands: Synthesis, Biological Evaluation, and Protein-Ligand X-ray Crystal Structure
Arun K. Ghosh et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
The Effect of Highly Active Antiretroviral Therapy on the Survival of HIV-Infected Children in a Resource-Deprived Setting: A Cohort Study
Andrew Edmonds et al.
PLOS MEDICINE (2011)
Features and development of Coot
P. Emsley et al.
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2010)
The development of antiretroviral therapy and its impact on the HIV-1/AIDS pandemic
Samuel Broder
ANTIVIRAL RESEARCH (2010)
Amprenavir complexes with HIV-1 protease and its drug-resistant mutants altering hydrophobic clusters
Chen-Hsiang Shen et al.
FEBS JOURNAL (2010)
In Vitro Selection of Highly Darunavir-Resistant and Replication-Competent HIV-1 Variants by Using a Mixture of Clinical HIV-1 Isolates Resistant to Multiple Conventional Protease Inhibitors
Yasuhiro Koh et al.
JOURNAL OF VIROLOGY (2010)
Autocatalytic maturation, physical/chemical properties, and crystal structure of Group N HIV-1 protease: Relevance to drug resistance
Jane M. Sayer et al.
PROTEIN SCIENCE (2010)
Characterization of virologic failure patients on darunavir/ritonavir in treatment-experienced patients
Sandra De Meyer et al.
AIDS (2009)
P-Glycoprotein Mediates Efflux Transport of Darunavir in Human Intestinal Caco-2 and ABCB1 Gene-Transfected Renal LLC-PK1 Cell Lines
Hiromi Fujimoto et al.
BIOLOGICAL & PHARMACEUTICAL BULLETIN (2009)
Demonstration of Sustained Drug-Resistant Human Immunodeficiency Virus Type 1 Lineages Circulating among Treatment-Naive Individuals
Stephane Hue et al.
JOURNAL OF VIROLOGY (2009)
Structure, function and regulation of P-glycoprotein and its clinical relevance in drug disposition
S. -F. Zhou
XENOBIOTICA (2008)
Design of HIV protease inhibitors targeting protein backbone: An effective strategy for combating drug resistance
Arun K. Ghosh et al.
ACCOUNTS OF CHEMICAL RESEARCH (2008)
Darunavir, a conceptually new HIV-1 protease inhibitor for the treatment of drug-resistant HIV
Arun K. Ghosh et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2007)
Tagged hypervalent iodine reagents:: A new purification concept based on ion exchange through SN2 substitution
Eike Kunst et al.
ORGANIC LETTERS (2007)
Phaser crystallographic software
Airlie J. McCoy et al.
JOURNAL OF APPLIED CRYSTALLOGRAPHY (2007)
Ultra-high resolution crystal structure of HIV-1 protease mutant reveals two binding sites for clinical inhibitor TMC114
Andrey Y. Kovalevsky et al.
JOURNAL OF MOLECULAR BIOLOGY (2006)
Structure-based design of novel HIV-1 protease inhibitors to combat drug resistance
Arun K. Ghosh et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
TMC114, a novel human immunodeficiency virus type 1 protease inhibitor active against protease inhibitor-resistant viruses, including a broad range of clinical isolates
S De Meyer et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2005)
High resolution crystal structures of HIV-1 protease with a potent non-peptide inhibitor (UIC-94017) active against multi-drug-resistant clinical strains
YF Tie et al.
JOURNAL OF MOLECULAR BIOLOGY (2004)
Coot:: model-building tools for molecular graphics
P Emsley et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2004)
Novel bis-tetrahydrofuranylurethane-containin nonpeptidic protease inhibitor (PI) UIC-94017 (TMC114) with potent activity against multi-PI-resistant human immunodeficiency virus in vitro
Y Koh et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2003)
A graphical user interface to the CCP4 program suite
E Potterton et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2003)
The mechanisms that control intracellular penetration of the HIV protease inhibitors
PG Hoggard et al.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2003)
Fluorine substituent effects (on bioactivity)
BE Smart
JOURNAL OF FLUORINE CHEMISTRY (2001)
The Protein Data Bank
HM Berman et al.
NUCLEIC ACIDS RESEARCH (2000)