Journal
CHEMISTRY OF NATURAL COMPOUNDS
Volume 55, Issue 6, Pages 1090-1093Publisher
SPRINGER
DOI: 10.1007/s10600-019-02901-6
Keywords
Dendronephthya mucronata; Nephtheidae; steroid; NO formation
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Funding
- Vietnam Academy of Science and Technology [QTRU01.04/18-19, QTRU04.04/18-19]
- Russian Foundation for Basic Research [18-53-54002 Vet_a]
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Four pregnane-type steroids including the new compound 5-alpha-pregn-20-en-3,6-dione (1) and two known cholestane-type steroids were isolated from the MeOH extract of the octocoral Dendronephthya mucronata. The structures of the compounds were elucidated using spectral data (PMR and C-13 NMR, HSQC, HMBC, H-1-H-1 COSY, NOESY, HR-QTOF-MS) and comparisons with previously published information. The steroids exhibited moderate or weak inhibitory effects on inflammatory lipopolysaccharide-induced NO formation in RAW264.7 murine macrophage cells.
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