Journal
CHEMICAL ENGINEERING JOURNAL
Volume 375, Issue -, Pages -Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.cej.2019.122048
Keywords
Konjac hydrogel; Polydopamine; Tumor therapy; 5-FU; Photothermal
Categories
Funding
- National Natural Science Foundation of China [51702214]
- Shanghai Sailing Program [17YF1412600]
- Shanghai Committee of Science and Technology
Ask authors/readers for more resources
Featured with three-dimensional network structure, polymer hydrogels have found tremendous applications in biomedical fields. In this study, therapeutic-laden Konjac glucomannan (KGM) hydrogel was prepared by injecting polydopamine (PDA)/5-fluorouracil (5-FU)/calcium folinate (CF)/KGM alkaline solution to the target area, for the synergistic tumor photothermal and chemotherapy. In alkaline solution, dopamine can be synchronously polymerized to form PDA, while KGM can be hydrolyzed and transformed into a thermally irreversible KGM hydrogel. Besides, the alkaline condition can increase the solubility of 5-FU. The hydrogel matrix can control the release of 5-FU and CF. PDA renders the composite hydrogel excellent tumor photothermal therapy ability. Moreover, CF can be used as a synergist to enhance the tumor chemotherapy efficiency of 5-FU. With convenient handling, excellent photothermal conversion ability and high biocompatibility, the multifunctional hydrogel system is anticipated to find a promising translational potential in clinical therapeutic applications.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available