Journal
CHEMICAL BIOLOGY & DRUG DESIGN
Volume 95, Issue 1, Pages 162-173Publisher
WILEY
DOI: 10.1111/cbdd.13632
Keywords
antibacterial; imidazo[1; 2-alpha]pyridine; molecular docking; pyrazole; tandem reaction
Ask authors/readers for more resources
A library of novel pyrazole-imidazo[1,2-alpha]pyridine scaffolds was designed and synthesized through a one-pot three-component tandem reaction. The structures of synthesized conjugates were confirmed by spectroscopic techniques (NMR, IR and HRMS). In vitro antibacterial evaluation of the twelve synthesized molecules (7a, 8a-k) against methicillin-resistant Staphylococcus aureus and normal strains of Escherichia coli, Salmonella typhimurium, Klebsiella pneumonia and Pseudomonas aeruginosa established 8b, 8d, 8e, 8h and 8i as potent antibacterial agents with superior minimum bactericidal concentration, compared with standard drug ciprofloxacin. Molecular docking studies of all active compounds into the binding site of glucosamine-6-phosphate synthase were further performed in order to have a comprehensive understanding of putative binding modes within the active sites of the receptor.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available