Journal
CHEMICAL BIOLOGY & DRUG DESIGN
Volume 95, Issue 1, Pages 16-47Publisher
WILEY
DOI: 10.1111/cbdd.13633
Keywords
anticancer activity; anti-inflammatory; antimicrobial; antioxidant; antitubercular; oxazines
Funding
- Chinese Academy of Sciences (CAS) [2016PM032]
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Oxazines have brought much synthetic interest due to their extensive biological activities. These are the important category of heterocycles, which may be formally derived from benzene and its reduction products by convenient substitution of carbon (and hydrogen) atoms by nitrogen and oxygen. In the last few decades, oxazine derivatives have documented as worthy synthetic intermediates and also blessed with notable sedative, analgesic, anticonvulsant, antipyretic, antimicrobial, antitubercular, antimalarial, antioxidant, and anticancer activities. Nowadays, it is important to develop new classes of compounds with more effective mechanisms due to drug resistance activity in which the ability of drug to effectively treat disease can be reduced. The aim of the article is to collect and make a more generalized review on the synthesis of oxazine derivatives and their pharmaceutical and biological activities. We hope this review will provide ample references for the researchers concerned with azines in generally and oxazines in particular.
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