Journal
CEREBRAL CORTEX
Volume 30, Issue 3, Pages 1499-1515Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhz181
Keywords
adult neurogenesis; axon initial segment; complex cells; doublecortin; tangled cells
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Funding
- Paracelsus Medical University Research Fund (PMU-FFF) [R-16/04/084-BEN, R-14/04/063-KON]
- Austrian Science Fund (FWF) [F44010, F4413-B23]
- German National Academic Foundation
- Spanish Ministry of Economy and Competitiveness [SAF2015-68436-R]
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The extent of functional maturation and integration of nonproliferative neuronal precursors, becoming neurons in the adult murine piriform cortex, is largely unexplored. We thus questioned whether precursors eventually become equivalent to neighboring principal neurons or whether they represent a novel functional network element. Adult brain neuronal precursors and immature neurons (complex cells) were labeled in transgenic mice (DCX-DsRed and DCX-CreER(T2)/flox-EGFP), and their cell fate was characterized with patch clamp experiments and morphometric analysis of axon initial segments. Young (DCX+) complex cells in the piriform cortex of 2- to 4-month-old mice received sparse synaptic input and fired action potentials at low maximal frequency, resembling neonatal principal neurons. Following maturation, the synaptic input detected on older (DCX-) complex cells was larger, but predominantly GABAergic, despite evidence of glutamatergic synaptic contacts. Furthermore, the rheobase current of old complex cells was larger and the maximal firing frequency was lower than those measured in neighboring age-matched principal neurons. The striking differences between principal neurons and complex cells suggest that the latter are a novel type of neuron and new coding element in the adult brain rather than simple addition or replacement for preexisting network components.
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