Journal
CELLULAR AND MOLECULAR NEUROBIOLOGY
Volume 40, Issue 2, Pages 215-228Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10571-019-00757-6
Keywords
TAAR1; RO5263397; Attention; Impulsivity; Cognitive flexibility; Rats
Categories
Ask authors/readers for more resources
Trace amine-associated receptor 1 (TAAR1) is a widely recognized new perspective target for the neuropsychiatric pharmacological treatment. Despite a growing number of studies investigating TAAR1 role in the animal models of different pathologies, information of TAAR1 agonists impact on executive cognitive functions is limited. The goal of the present study was to evaluate the activity of highly selective partial TAAR1 agonist RO5263397 on various executive cognitive functions. The results of the present study demonstrated that the pretreatment with RO5263397 was able to increase attention and decrease cognitive flexibility in rats. The analysis of the RO5263397 action on impulsivity demonstrated that the TAAR1 activation failed to affect premature responding but was able to slightly modify impulsive choice. Problem solving was resistant to the pharmacological intervention.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available