Journal
CELL TRANSPLANTATION
Volume 28, Issue 1_SUPPL, Pages 87S-99SPublisher
SAGE PUBLICATIONS INC
DOI: 10.1177/0963689719891134
Keywords
human umbilical cord mesenchymal stromal cells; dopaminergic neurons; Parkinson's disease; apoptosis; oxidative stress
Funding
- Stem Cell and Translation National Key Project [2016YFA0101403]
- National Natural Science Foundation of China [81973351, 81661130160, 81422014, 81561138004]
- Beijing Municipal Natural Science Foundation [5142005]
- Beijing Talents Foundation [2017000021223TD03]
- Support Project of High-level Teachers in Beijing Municipal Universities in the Period of 13th Five-year Plan [CIT TCD20180333]
- Beijing Medical System High Level Talent Award [2015-3-063]
- Beijing Municipal Health Commission Fund [PXM 2018_026283_000002]
- Beijing One Hundred, Thousand, and Ten Thousand Talents Fund [2018A03]
- Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support [ZYLX201706]
- Royal Society-Newton Advanced Fellowship [NA150482]
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Oxidative stress is an important cause of dopaminergic (DA) neuron apoptosis in Parkinson's disease (PD). Mesenchymal stromal cells (MSCs) possess antioxidative features. In this study, we investigated whether MSCs could reduce oxidative stress and protect DA neurons from apoptosis by intravenous (I.V.) injection in the early stage of a 6-hydroxydopamine (6-OHDA)-induced PD model. MSCs were injected into the tail vein of mice, and behavioral tests, immunofluorescence staining, western blot, and oxidative stress levels were assessed at different time points. After 6-OHDA exposure, DA neuron apoptosis was detected, together with severe oxidative stress in brain and periphery. Compared with the non-transplanted sham controls, motor function in the 6-OHDA-lesioned group after I.V. injection of MSCs was significantly improved, and the levels of DA neuron apoptosis and oxidative stress decreased. The results demonstrate that MSCs can rescue DA neurons from ongoing apoptosis by reducing oxidative stress, and provide insights on developing new therapeutic strategies to offset the degenerative process of PD.
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