Journal
CELL STRESS & CHAPERONES
Volume 24, Issue 6, Pages 1013-1026Publisher
SPRINGER
DOI: 10.1007/s12192-019-01040-9
Keywords
Protein quality control; Protein homeostasis; Chaperones; Protein folding disease
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Funding
- Deutsche Forschungsgemeinschaft (DFG) [SFB1036]
- European Union's Joint Program on Neurodegenerative Diseases (JPND Project Protest, Netherlands, Netherlands Organization for Scientific Research (ZonMw))
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The cellular protein quality control machinery with its central constituents of chaperones and proteases is vital to maintain protein homeostasis under physiological conditions and to protect against acute stress conditions. Imbalances in protein homeostasis also are keys to a plethora of genetic and acquired, often age-related, diseases as well as aging in general. At the EMBO Workshop, speakers covered all major aspects of cellular protein quality control, from basic mechanisms at the molecular, cellular, and organismal level to medical translation. In this report, the highlights of the meeting will be summarized.
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