Journal
CARDIOVASCULAR RESEARCH
Volume 116, Issue 5, Pages 885-893Publisher
OXFORD UNIV PRESS
DOI: 10.1093/cvr/cvz308
Keywords
Pulmonary hypertension; Pulmonary vascular remodelling; Endothelial cells; Smooth muscle cells; Adventitial fibroblasts; Innate and adaptive immunity
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This review seeks to provide an update of preclinical findings and available clinical data on the chronic persistent inflammation and its direct rote on the pulmonary arterial hypertension (PAH) progression. We reviewed the different mechanisms by which the inflammatory and immune pathways contribute to the structural and functional changes occurring in the three vascular compartments: the tunica intima, tunica media, and tunica adventitia. We also discussed how these inflammatory mediator changes may serve as a biomarker of the PAH progression and summarize unanswered questions and opportunities for future studies in this area. [GRAPHICS] .
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