Journal
BIOLOGICAL CHEMISTRY
Volume 397, Issue 7, Pages 617-635Publisher
WALTER DE GRUYTER GMBH
DOI: 10.1515/hsz-2016-0137
Keywords
autophagy; cell death; mitochondria; mitophagy; Parkin
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Funding
- Biotechnology and Biological Sciences Research Council Funding Source: Medline
- Cancer Research UK Funding Source: Medline
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Since entering our cells in an endosymbiotic event one billion years ago, mitochondria have shaped roles for themselves in metabolism, inflammation, calcium storage, migration, and cell death. Given this critical role in cellular homeostasis it is essential that they function correctly. Equally critical is the ability of a cell to remove damaged or superfluous mitochondria to avoid potential deleterious effects. In this review we will discuss the various mechanisms of mitochondrial clearance, with a particular focus on Parkin/PINK1-mediated mitophagy, discuss the impact of altered mitophagy in ageing and disease, and finally consider potential therapeutic benefits of targeting mitophagy.
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