Journal
BRAIN STRUCTURE & FUNCTION
Volume 224, Issue 9, Pages 3031-3044Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00429-019-01969-8
Keywords
Independent component analysis (ICA); Source-based morphometry (SBM); Multivariate analysis; Voxel-based morphometry (VBM); Univariate analysis; Nonlinear independent component analysis (NICE); Biclustered independent component analysis (B-ICA)
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Funding
- NIH [1R01MH094524, P20GM103472, 1R01EB006841, R01EB005846]
- NSF [1539067]
- Indian Institute of Technology Guwahati
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In this paper, we review and discuss brain imaging studies which have used the source-based morphometry (SBM) approach over the past decade. SBM is a data-driven linear multivariate approach for decomposing structural brain imaging data into commonly covarying imaging components and subject-specific loading parameters. It is a well-established technique which has predominantly been used to study neuroanatomic differences between healthy controls and patients with neuropsychiatric diseases. We start by discussing the advantages of this technique over univariate analysis for imaging studies, followed by a discussion of results from recent studies which have successfully applied this methodology. We also present recent extensions of this framework including nonlinear SBM, biclustered independent component analysis (B-ICA) and conclude with the possible directions of work for future.
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