Journal
BIOLOGICAL & PHARMACEUTICAL BULLETIN
Volume 39, Issue 7, Pages 1130-1136Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/bpb.b16-00045
Keywords
Alzheimer's disease; Cinnamomum loureirii; acetylcholine; acetylcholinesterase inhibitor
Categories
Funding
- Ministry of Agriculture, Food and Rural Affairs, Republic of Korea
Ask authors/readers for more resources
The pathogenesis of Alzheimer's disease (AD) has been linked to the deficiency of neurotransmitter acetylcholine (ACh) in the brain, and the main treatment strategy for improving AD symptoms is the inhibition of acetylcholinesterase (AChE) activity. In the present study, we aimed to identify potent AChE inhibitors from Cinnamomum loureirii extract via bioassay-guided fractionation. We demonstrated that the most potent AChE inhibitor present in the C. loureirii extract was 2,4-bis(1,1-dimethylethyl)phenol. To confirm the antiamnesic effects of the ethanol extract of C. loureirii, mice were intraperitoneally injected with the neurotoxin trimethyltin (2.5mg/kg) to induce cognitive dysfunction, and performance in the Y-maze and passive avoidance tests was assessed. Treatment with C. loureirii extract significantly improved performance in both behavioral tests, suggesting that this extract may be neuroprotective and therefore beneficial in preventing or ameliorating the degenerative processes of AD, potentially by restoring cholinergic function.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available