Related references
Note: Only part of the references are listed.RNA as a key factor in driving or preventing self-assembly of the TAR DNA-binding protein 43
Elsa Zacco et al.
JOURNAL OF MOLECULAR BIOLOGY (2019)
Regulatory Role of RNA Chaperone TDP-43 for RNA Misfolding and Repeat-Associated Translation in SCA31
Taro Ishiguro et al.
NEURON (2017)
Endocytosis regulates TDP-43 toxicity and turnover
Guangbo Liu et al.
NATURE COMMUNICATIONS (2017)
Functional and dynamic polymerization of the ALS-linked protein TDP-43 antagonizes its pathologic aggregation
Tariq Afroz et al.
NATURE COMMUNICATIONS (2017)
Massive transcriptome sequencing of human spinal cord tissues provides new insights into motor neuron degeneration in ALS
Anna Maria D'Erchia et al.
SCIENTIFIC REPORTS (2017)
Quantitative analysis of cryptic splicing associated with TDP-43 depletion
Jack Humphrey et al.
BMC MEDICAL GENOMICS (2017)
The heat shock response plays an important role in TDP-43 clearance: evidence for dysfunction in amyotrophic lateral sclerosis
Han-Jou Chen et al.
BRAIN (2016)
Prion-like domains as epigenetic regulators, scaffolds for subcellular organization, and drivers of neurodegenerative disease
Zachary M. March et al.
BRAIN RESEARCH (2016)
Dysregulated axonal RNA translation in amyotrophic lateral sclerosis
Kyota Yasuda et al.
WILEY INTERDISCIPLINARY REVIEWS-RNA (2016)
RNAseq Analyses Identify Tumor Necrosis Factor-Mediated Inflammation as a Major Abnormality in ALS Spinal Cord
David G. Brohawn et al.
PLOS ONE (2016)
TDP-35 sequesters TDP-43 into cytoplasmic inclusions through binding with RNA
Mei-Xia Che et al.
FEBS LETTERS (2015)
Functional complementation in Drosophila to predict the pathogenicity of TARDBP variants: evidence for a loss-of-function mechanism
Lies Vanden Broeck et al.
NEUROBIOLOGY OF AGING (2015)
TDP-43 Proteinopathy and ALS: Insights into Disease Mechanisms and Therapeutic Targets
Emma L. Scotter et al.
NEUROTHERAPEUTICS (2015)
TDP-43 repression of nonconserved cryptic exons is compromised in ALS-FTD
Jonathan P. Ling et al.
SCIENCE (2015)
A revision of the El Escorial criteria-2015
Albert Ludolph et al.
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration (2015)
Wild type human TDP-43 potentiates ALS-linked mutant TDP-43 driven progressive motor and cortical neuron degeneration with pathological features of ALS
Jacqueline C. Mitchell et al.
ACTA NEUROPATHOLOGICA COMMUNICATIONS (2015)
Nuclear TDP-43 causes neuronal toxicity by escaping from the inhibitory regulation by hnRNPs
Hiroaki Suzuki et al.
HUMAN MOLECULAR GENETICS (2015)
Binding of TDP-43 to the 3′UTR of Its Cognate mRNA Enhances Its Solubility
Yulong Sun et al.
BIOCHEMISTRY (2014)
Experimental trials in amyotrophic lateral sclerosis: a review of recently completed, ongoing and planned trials using existing and novel drugs
Namita A. Goyal et al.
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2014)
UBE2E Ubiquitin-conjugating Enzymes and Ubiquitin Isopeptidase Y Regulate TDP-43 Protein Ubiquitination
Friederike Hans et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Targeted high-throughput sequencing identifies a TARDBP mutation as a cause of early-onset FTD without motor neuron disease
Matthis Synofzik et al.
NEUROBIOLOGY OF AGING (2014)
The crystal structure of TDP-43 RRM1-DNA complex reveals the specific recognition for UG- and TG-rich nucleic acids
Pan-Hsien Kuo et al.
NUCLEIC ACIDS RESEARCH (2014)
Disease causing mutants of TDP-43 nucleic acid binding domains are resistant to aggregation and have increased stability and half-life
James A. Austin et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Stages of pTDP-43 Pathology in Amyotrophic Lateral Sclerosis
Johannes Brettschneider et al.
ANNALS OF NEUROLOGY (2013)
Loss of TDP-43 causes age-dependent progressive motor neuron degeneration
Yohei Iguchi et al.
BRAIN (2013)
Loss and gain of Drosophila TDP-43 impair synaptic efficacy and motor control leading to age-related neurodegeneration by loss-of-function phenotypes
Danielle C. Diaper et al.
HUMAN MOLECULAR GENETICS (2013)
Molecular basis of UG-rich RNA recognition by the human splicing factor TDP-43
Peter J. Lukavsky et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2013)
Abnormal RNA structures (RNA foci) containing a penta-nucleotide repeat (UGGAA)n in the Purkinje cell nucleus is associated with spinocerebellar ataxia type 31 pathogenesis
Yusuke Niimi et al.
NEUROPATHOLOGY (2013)
Characterizing TDP-43 interaction with its RNA targets
Amit Bhardwaj et al.
NUCLEIC ACIDS RESEARCH (2013)
Inhibition of TDP-43 Aggregation by Nucleic Acid Binding
Yi-Chen Huang et al.
PLOS ONE (2013)
Hexanucleotide Repeats in ALS/FTD Form Length-Dependent RNA Foci, Sequester RNA Binding Proteins, and Are Neurotoxic
Youn-Bok Lee et al.
CELL REPORTS (2013)
The ALS disease protein TDP-43 is actively transported in motor neuron axons and regulates axon outgrowth
Claudia Fallini et al.
HUMAN MOLECULAR GENETICS (2012)
Targeted Depletion of TDP-43 Expression in the Spinal Cord Motor Neurons Leads to the Development of Amyotrophic Lateral Sclerosis-like Phenotypes in Mice
Lien-Szu Wu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Caenorhabditis elegans RNA-processing Protein TDP-1 Regulates Protein Homeostasis and Life Span
Tao Zhang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Alteration of POLDIP3 Splicing Associated with Loss of Function of TDP-43 in Tissues Affected with ALS
Atsushi Shiga et al.
PLOS ONE (2012)
Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability
Bilada Bilican et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
TDP-1/TDP-43 Regulates Stress Signaling and Age-Dependent Proteotoxicity in Caenorhabditis elegans
Alexandra Vaccaro et al.
PLOS GENETICS (2012)
Valosin Containing Protein Associated Fronto-Temporal Lobar Degeneration:Clinical Presentation, Pathologic Features and Pathogenesis
C. C. Weihl
Current Alzheimer Research (2011)
TDP-43 regulates its mRNA levels through a negative feedback loop
Youhna M. Ayala et al.
EMBO JOURNAL (2011)
TAR DNA-binding protein 43 (TDP-43) regulates stress granule dynamics via differential regulation of G3BP and TIA-1
Karli K. McDonald et al.
HUMAN MOLECULAR GENETICS (2011)
Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice
Lionel M. Igaz et al.
JOURNAL OF CLINICAL INVESTIGATION (2011)
Local RNA Translation at the Synapse and in Disease
Liqun Liu-Yesucevitz et al.
JOURNAL OF NEUROSCIENCE (2011)
Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43
Magdalini Polymenidou et al.
NATURE NEUROSCIENCE (2011)
Characterizing the RNA targets and position-dependent splicing regulation by TDP-43
James R. Tollervey et al.
NATURE NEUROSCIENCE (2011)
Neuronal Function and Dysfunction of Drosophila dTDP
Meng-Jau Lin et al.
PLOS ONE (2011)
Loss of murine TDP-43 disrupts motor function and plays an essential role in embryogenesis
Brian C. Kraemer et al.
ACTA NEUROPATHOLOGICA (2010)
Nuclear import impairment causes cytoplasmic trans-activation response DNA-binding protein accumulation and is associated with frontotemporal lobar degeneration
Agnes L. Nishimura et al.
BRAIN (2010)
Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6
Fabienne C. Fiesel et al.
EMBO JOURNAL (2010)
Nuclear factor TDP-43 can affect selected microRNA levels
Emanuele Buratti et al.
FEBS JOURNAL (2010)
Neurotoxic effects of TDP-43 overexpression in C-elegans
Peter E. A. Ash et al.
HUMAN MOLECULAR GENETICS (2010)
TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration
Clotilde Lagier-Tourenne et al.
HUMAN MOLECULAR GENETICS (2010)
TDP-43 Is a Developmentally Regulated Protein Essential for Early Embryonic Development
Chantelle F. Sephton et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Cytoplasmic Mislocalization of TDP-43 Is Toxic to Neurons and Enhanced by a Mutation Associated with Familial Amyotrophic Lateral Sclerosis
Sami J. Barmada et al.
JOURNAL OF NEUROSCIENCE (2010)
TDP-43 and FUS in amyotrophic lateral sclerosis and frontotemporal dementia
Ian R. A. Mackenzie et al.
LANCET NEUROLOGY (2010)
Progressive motor weakness in transgenic mice expressing human TDP-43
Nancy R. Stallings et al.
NEUROBIOLOGY OF DISEASE (2010)
ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS
Shuo-Chien Ling et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration
Hans Wils et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Phosphorylated and ubiquitinated TDP-43 pathological inclusions in ALS and FTLD-U are recapitulated in SH-SY5Y cells
Takashi Nonaka et al.
FEBS LETTERS (2009)
Depletion of TDP-43 affects Drosophila motoneurons terminal synapsis and locomotive behavior
Fabian Feiguin et al.
FEBS LETTERS (2009)
TDP-43 Is Intrinsically Aggregation-prone, and Amyotrophic Lateral Sclerosis-linked Mutations Accelerate Aggregation and Increase Toxicity
Brian S. Johnson et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
TDP-43 is recruited to stress granules in conditions of oxidative insult
Claudia Colombrita et al.
JOURNAL OF NEUROCHEMISTRY (2009)
TARDBP Variation Associated with Frontotemporal Dementia, Supranuclear Gaze Palsy, and Chorea
Gabor G. Kovacs et al.
MOVEMENT DISORDERS (2009)
Genetics of motor neuron disorders: new insights into pathogenic mechanisms
Patrick A. Dion et al.
NATURE REVIEWS GENETICS (2009)
Clinical heterogeneity in 3 unrelated families linked to VCP p.Arg159His
J. van der Zee et al.
NEUROLOGY (2009)
TDP-43 neuropathology is similar in sporadic amyotrophic lateral sclerosis with or without TDP-43 mutations
R. Pamphlett et al.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2009)
Functional mapping of the interaction between TDP-43 and hnRNP A2 in vivo
Andrea D'Ambrogio et al.
NUCLEIC ACIDS RESEARCH (2009)
Structural insights into TDP-43 in nucleic-acid binding and domain interactions
Pan-Hsien Kuo et al.
NUCLEIC ACIDS RESEARCH (2009)
Amyotrophic lateral sclerosis
Lokesh C. Wijesekera et al.
ORPHANET JOURNAL OF RARE DISEASES (2009)
Evidence of multisystem disorder in whole-brain map of pathological TDP-43 in amyotrophic lateral sclerosis
Felix Geser et al.
ARCHIVES OF NEUROLOGY (2008)
Disturbance of nuclear and cytoplasmic TAR DNA-binding protein (TDP-43) induces disease-like redistribution, sequestration, and aggregate formation
Matthew J. Winton et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Structural determinants of the cellular localization and shuttling of TDP-43
Youhna M. Ayala et al.
JOURNAL OF CELL SCIENCE (2008)
TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis
Edor Kabashi et al.
NATURE GENETICS (2008)
Protein Solubility and Folding Enhancement by Interaction with RNA
Seong Il Choi et al.
PLOS ONE (2008)
TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis
Jemeen Sreedharan et al.
SCIENCE (2008)
Novel Mutations in TARDBP(TDP-43) in Patients with Familial Amyotrophic Lateral Sclerosis
Nicola J. Rutherford et al.
PLOS GENETICS (2008)
TDP-43 immunoreactivity in neuronal inclusions in familial amyotrophic lateral sclerosis with or without SOD1 gene mutation
Chun-Feng Tan et al.
ACTA NEUROPATHOLOGICA (2007)
Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations
Ian R. A. Mackenzie et al.
ANNALS OF NEUROLOGY (2007)
TDP-43 in the ubiquitin pathology of frontotemporal dementia with VCP gene mutations
Manuela Neumann et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2007)
Amyotrophic lateral sclerosis in an urban setting - A population based study of inner city London
Clare A. Johnston et al.
JOURNAL OF NEUROLOGY (2006)
Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
Manuela Neumann et al.
SCIENCE (2006)
TDP-43 binds heterogeneous nuclear ribonucleoprotein A/B through its C-terminal tail - An important region for the inhibition of cystic fibrosis transmembrane conductance regulator exon 9 splicing
E Buratti et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Delocalization of the multifunctional RNA splicing factor TLS/FUS in hippocampal neurones: exclusion from the nucleus and accumulation in dendritic granules and spine heads
A Belly et al.
NEUROSCIENCE LETTERS (2005)
Human, Drosophila, and C-elegans TDP43:: Nucleic acid binding properties and splicing regulatory function
YM Ayala et al.
JOURNAL OF MOLECULAR BIOLOGY (2005)
Neuronal and glial inclusions in frontotemporal dementia with or without motor neuron disease are immunopositive for p62
T Arai et al.
NEUROSCIENCE LETTERS (2003)
Characterization and functional implications of the RNA binding properties of nuclear factor TDP-43, a novel splicing regulator of CFTR exon 9
E Buratti et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
A method for efficient isotopic labeling of recombinant proteins
J Marley et al.
JOURNAL OF BIOMOLECULAR NMR (2001)