Journal
BMC BIOLOGY
Volume 17, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s12915-019-0704-y
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Funding
- Graduate School of Medical Sciences, University of Groningen
- Netherlands Organization for Scientific Research (NWO) Vidi grant [NWO-VIDI 016.178.056]
- European Research Council (ERC) [715772]
- NWO-Vidi [NWO-VIDI 864.13.013]
- CardioVasculair Onderzoek Nederland [CVON 2018-27]
- ERC advanced grant [FP/2007-2013/ERC, 2012-322698]
- NWO Spinoza prize [NWO SPI 92-266]
- NWO Gravitation Netherlands Organ-on-Chip Initiative [024.003.001]
- Stiftelsen Kristian Gerhard Jebsen foundation (Norway)
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The human gut harbors a complex ecosystem of microorganisms, including bacteria and viruses. With the rise of next-generation sequencing technologies, we have seen a quantum leap in the study of humangut-inhabiting bacteria, yet the viruses that infect these bacteria, known as bacteriophages, remain underexplored. In this review, we focus on what is known about the role of bacteriophages in human health and the technical challenges involved in studying the gut virome, of which they are a major component. Lastly, we discuss what can be learned from studies of bacteriophages in other ecosystems.
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