Journal
BIOSENSORS & BIOELECTRONICS
Volume 150, Issue -, Pages -Publisher
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2019.111849
Keywords
Salinomycin; 3D rose like La3+@ ZrO2/ RGO; Sintering; Selectivity; Pharmacokinetic study
Categories
Funding
- Deanship of Scientific Research, Najran University [NU/MID/16/093]
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An innovative electrochemical nanoprobe, for analysis of salinomycin (SAL), was proposed. The nanoprobe based on decoration of glassy carbon electrode (GCE) with 3D rose like La3+@ ZrO2 supported on reduced graphene oxide (RGO) nanosheets. The 3D rose like La3+@ ZrO2 was synthesized via sintering process. The successful decoration of 3D rose like La3+@ ZrO2 on the surface of RGO was characterized using different spectroscopic and analytical techniques. The obtained voltammetric results confirmed the good electrochemical performance of 3D rose like La3+@ ZrO2 in terms of lower peak potential (E-pc) and higher cathodic current (I-pc). Moreover, the modified nanoprobe showed wide linearity range (0.34-115 x 10(-8) M), lower detection limit (0.11 x 10(-8) M) and higher selectivity. Besides, the nanocomposite showed good applicability for analysis of SAL in biological fluids and during pharmacokinetic evaluation in rabbit plasma. The obtained results opens a new venue for the determination of futuristic drug, SAL, during pharmacokinetic and pharmacodynamics studies.
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