Journal
BIOMEDICINE & PHARMACOTHERAPY
Volume 118, Issue -, Pages -Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2019.109203
Keywords
Paraptosis; Small-Molecule compounds; Cancer therapy; Programmed cell death
Funding
- National Natural Science Foundation of China [21772131, 81472162, 81872535]
- Science and Technology Department of Sichuan Province [2017JY0075, 2019YFSY0004]
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According to its different occurrence mechanism, programmed cell death (PCD) is divided into apoptosis, autophagy, necrosis, paraptosis and so on. Paraptosis is morphologically different from apoptosis and autophagy, which exhibit cytoplasmic vacuolation derived from the ER, independent of caspase, absence of apoptotic morphology. Recent researches have implied that a variety of small molecule compounds, such as celastrol, curcumin, can induce paraptosis-associated cell death as the reagent to enhance anti-cancer activity. A better understanding of paraptosis will lay the foundation to develop new therapeutic strategies to treat human cancers that make full use of small-molecule compounds.
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