Journal
BIOMATERIALS
Volume 219, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2019.119366
Keywords
Bone tissue engineering; Bioactive coatings; Biomedical implants; Biomimetics
Funding
- Australian Research Council, Australia [DE180100775]
- Dementia Research Leadership Fellowship from the National Health and Medical Research Council, Australia [GNT1135687]
- Australian Research Council [DE180100775] Funding Source: Australian Research Council
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Biomedical implants have been widely used in various orthopedic treatments, including total hip arthroplasty, joint arthrodesis, fracture fixation, non-union, dental repair, etc. The modem research and development of orthopedic implants have gradually shifted from traditional mechanical support to a bioactive graft in order to endow them with better osteoinduction and osteoconduction. Inspired by structural and mechanical properties of natural bone, this review provides a panorama of current biological surface modifications for facilitating the interaction between medical implants and bone tissue and gives a future outlook for fabricating the next-generation multifunctional and smart implants by systematically biomimicking the physiological processes involved in formation and functioning of bones.
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