Journal
BIOGERONTOLOGY
Volume 21, Issue 2, Pages 155-171Publisher
SPRINGER
DOI: 10.1007/s10522-019-09849-8
Keywords
Mitochondria; Drosophila melanogaster; Reactive oxygen species; Antioxidant defence; Stress resistance
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Funding
- Ministry of Education and Science of Ukraine [0115U002304, 0117U006426]
- Academy of Finland (FinMIT Centre of Excellence Grant) [272376]
- European Research Council [232738]
- European Research Council (ERC) [232738] Funding Source: European Research Council (ERC)
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Mitochondrial alternative NADH dehydrogenase (aNDH) was found to extend lifespan when expressed in the fruit fly. We have found that fruit flies expressing aNDH from Ciona intestinalis (NDX) had 17-71% lifespan prolongation on media with different protein-tocarbohydrate ratios except NDX-expressing males that had 19% shorter lifespan than controls on a high protein diet. NDX-expressing flies were more resistant to organic xenobiotics, 2,4-dichlorophenoxyacetic acid and alloxan, and inorganic toxicant potassium iodate, and partially to sodium molybdate treatments. On the other hand, NDX-expressing flies were more sensitive to catechol and sodium chromate. Enzymatic analysis showed that NDX-expressing males had higher glucose 6-phosphate dehydrogenase activity, whilst both sexes showed increased glutathione S-transferase activity.
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