Journal
BIOINFORMATICS
Volume 32, Issue 12, Pages 1761-1765Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btw054
Keywords
-
Categories
Funding
- Spanish Ministry for Economy and Competitiveness [BIO2010-22109]
Ask authors/readers for more resources
Motivation: Many diseases are related by shared associated molecules and pathways, exhibiting comorbidities and common phenotypes, an indication of the continuous nature of the human pathological landscape. Although it is continuous, this landscape is always partitioned into discrete diseases when studied at the molecular level. Clinical signs are also important phenotypic descriptors that can reveal the molecular mechanisms that underlie pathological states, but have seldom been the subject of systemic research. Here, we quantify the modular nature of the clinical signs associated with genetic diseases in the human interactome. Results: We found that clinical signs are reflected as modules at the molecular network level, to at least to the same extent as diseases. They can thus serve as a valid complementary partition of the human pathological landscape, with implications for etiology research, diagnosis and treatment.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available