Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 518, Issue 3, Pages 565-572Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2019.08.088
Keywords
UPB1; Cell cycle; Transcription factor; Root growth
Categories
Funding
- National Natural Science Foundation of China [31570237, 31670235]
- National Basic Research Program of China [973 Program] [2015CB150100]
- Fundamental Research Funds for the Central Universities [SCU2019D013, SCU2018D006]
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Plant growth, development and interaction with the environment involve the action of transcription factor. bHLH proteins play an essential and often conserved role in the plant kingdom. However, bHLH proteins that participate in the cell division process are less well known. Here, we report that the bHLH transcription factor gene AtUPB1 is involved in mediating cell cycle progression and root development. In yeast cells, AtUPB1 inhibits cells proliferation and the cells had increased numbers of nuclei. UPB1 overexpression decreased the expression of the cell division marker CYCB1-1, and CDKA1 expression could overcome the defect of UPB1 overexpression. Moreover, UPB1 could directly bind to the promoter region of the SIM and SMR1 genes to regulate cell cycle. These results support a new role for AtUPB1 regulating root meristem development by mediating the expression of SIM/SMR1 genes. (C) 2019 Elsevier Inc. All rights reserved.
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