Journal
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
Volume 15, Issue -, Pages 2774-2781Publisher
BEILSTEIN-INSTITUT
DOI: 10.3762/bjoc.15.269
Keywords
apoptosis; biologically active; [2+2+2] cycloaddition; flow cytometry; spiro thiazolidinedione
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Funding
- Department of Science and Technology
- CSIR-New Delhi
- DST, New Delhi
- Russian Foundation for Basic Research [18-33-20058, 18-29-09068]
- RF [Sci. Sh.-5240.2018.3]
- Praj Industries
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We report a new synthetic approach to assemble spirothiazolidinediones via a [2 + 2 + 2] cyclotrimerization reaction and the derivatives were further functionalized through DA chemistry and click reaction. Using flow cytometry, it was shown for the first time that the new benzyl alcohol derivatives of thiazolidine-2,4-dione generated here are efficient apoptosis inducers in the HeLa, Hek293, U937, Jurkat, and K562 cell lines.
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