Journal
BIOFOULING
Volume 32, Issue 1, Pages 45-56Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/08927014.2015.1125888
Keywords
Actinomycin D; biofilm; hemolysis; hydrophobicity; Staphylococcus aureus
Funding
- National Research Foundation of Korea (NRF) - Korea government (MSIP) [2015R1A2A2A01004542]
- Priority Research Centers Program through the National Research Foundation of Korea (NRF) - Ministry of Education [2014R1A6A1031189]
- National Research Foundation of Korea [2015R1A2A2A01004542] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Staphylococcus aureus is a versatile human pathogen that produces diverse virulence factors, and its biofilm cells are difficult to eradicate due to their inherent ability to tolerate antibiotics. The anti-biofilm activities of the spent media of 252 diverse endophytic microorganisms were investigated using three S. aureus strains. An attempt was made to identify anti-biofilm compounds in active spent media and to assess their anti-hemolytic activities and hydrophobicities in order to investigate action mechanisms. Unlike other antibiotics, actinomycin D (0.5 mu g ml(-1)) from Streptomyces parvulus significantly inhibited biofilm formation by all three S. aureus strains. Actinomycin D inhibited slime production in S. aureus and it inhibited hemolysis by S. aureus and caused S. aureus cells to become less hydrophobic, thus supporting its anti-biofilm effect. In addition, surface coatings containing actinomycin D prevented S. aureus biofilm formation on glass surfaces. Given these results, FDA-approved actinomycin D warrants further attention as a potential antivirulence agent against S. aureus infections.
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