Journal
APPLIED SURFACE SCIENCE
Volume 506, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.apsusc.2019.144662
Keywords
Metal-organic framework; Cu2O/Cu@C composites; Core-shell structure; Uric acid biosensor; Anti-interference ability
Categories
Funding
- National Natural Science Foundation of China, China [21606217]
- Fundamental Research Funds for the Central Universities, China [PA2019GDQT0015, PA2019GDQT0022, JZ2019HGBZ0142]
Ask authors/readers for more resources
Uric acid (UA) is an important indicator for human metabolism, therefore it is of great significance to develop a sensitive and selective biosensor for monitoring UA and diagnosing relevant disorders. In this paper, porous Cu2O/Cu@C core-shell nanowires (NWs) are synthesized by thermal decomposition of HKUST-1 NWs. Subsequently the nanowires are used as electrode materials to fabricate UA biosensors. By controlling the conditions of calcination, we obtain composite particles consisting of cuprous oxide and copper nanoparticles which are wrapped within the nanowire shell formed by non-graphitic carbon material. These nanowires exhibit excellent electrocatalytic capability at low working potential that is beneficial for improving the anti-interference ability of UA biosensors. Furthermore, carbon and copper in the substrate accelerate electron transfer to substantially improve the sensitivity of the UA biosensors. Sensitivity of 330.5 mu A.mM(-1).cm(-2) and a linearity range from 0.05 to 1.15 mM (R-2 = 0.997) at a working potential of -0.5 V vs SCE are achieved. We also demonstrate the practicality of our biosensors for clinical applications by measuring the concentration of UA in diluted human urine.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available