Journal
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
Volume 45, Issue 3, Pages 340-343Publisher
CANADIAN SCIENCE PUBLISHING
DOI: 10.1139/apnm-2019-0554
Keywords
alternate-day fasting; calorie restriction; thyroid; subclinical hypothyroidism; weight loss; insulin resistance; obesity
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Funding
- National Institutes of Health ((NHLBI)) [R01HL106228]
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This study compared the weight loss efficacy of alternate-day fasting (ADF) versus daily calorie restriction (CR) in adults with subclinical hypothyroidism. After 6 months, body weight decreased (P < 0.001) similarly by ADF (-7% +/- 1%) and CR (-8% +/- 2%). Insulin resistance decreased (P < 0.05) more by ADF versus CR. Free thyroxin and thyroid-stimulating hormone remained unchanged. Thus, ADF and CR produce similar weight loss in this population, without affecting thyroid hormone levels. Novelty Intermittent fasting and daily restriction produce similar reductions in body weight in subjects with subclinical hypothyroidism.
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