Journal
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
Volume 104, Issue 2, Pages 475-488Publisher
SPRINGER
DOI: 10.1007/s00253-019-10224-3
Keywords
Kluyveromyces marxianus; Useful materials production; Transcriptome; Biotechnological tools; Glucose sensing; Mig1 regulation
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Funding
- Advanced Low Carbon Technology Research and Development Program - Japan Science and Technology Agency [JPMJAL1106]
- e-ASIA Joint Research Program (e-ASIA JRP) - Japan Science and Technology Agency [JPMJSC16E5]
- RISTEK-DIKTI
- Agricultural Research Development Agency of Thailand
- Ministry of Science and Technology of Laos
- Core to Core Program A. Advanced Research Networks - the Japan Society for the Promotion of Science
- National Research Council of Thailand
- Ministry of Science and Technology in Vietnam
- National Univ. of Laos
- Univ. of Brawijaya
- Beuth Univ. of Applied Science Berlin
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Among the so-called non-conventional yeasts, Kluyveromyces marxianus has extremely potent traits that are suitable for industrial applications. Indeed, it has been used for the production of various enzymes, chemicals, and macromolecules in addition to utilization of cell biomass as nutritional materials, feed and probiotics. The yeast is expected to be an efficient ethanol producer with advantages over Saccharomyces cerevisiae in terms of high growth rate, thermotolerance and a wide sugar assimilation spectrum. Results of comprehensive analyses of its genome and transcriptome may accelerate studies for applications of the yeast and may further increase its potential by combination with recent biotechnological tools including the CRISPR/Cas9 system. We thus review published studies by merging with information obtained from comprehensive data including genomic and transcriptomic data, which would be useful for future applications of K. marxianus.
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