Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 64, Issue 1, Pages -Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.01326-19
Keywords
tigecycline; tet(X5); Acinetobacter baumannii
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Funding
- National Key Research and Development Program of China [2018YFD0500300]
- National Natural Science Foundation of China [81572033, 31930110, 81661138002]
- Medical Research Council [MR/P007295/1, DETER-XDRE-CHINA-HUB (MRC MR/S013768/1)]
- BBSRC [BB/R012776/1] Funding Source: UKRI
- MRC [G1100135, MR/N028317/1, MR/P007295/1, MR/S013768/1] Funding Source: UKRI
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A novel, plasmid-mediated, high-level tigecycline resistance tet(X) gene variant, tet(X5), was detected in a clinical Acinetobacter baumannii isolate from China in 2017. Tet(X5) shows 84.5% and 90.5% amino acid identity to Tet(X3) and Tet(X4), respectively, with similar binding sites and a comparable affinity for tetracyclines. The tet(X5)-containing plasmid could only be transferred to A. baumannii via electro-transformation. This report follows the recent study describing the identification of tet(X3) and tet(X4).
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