Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 64, Issue 2, Pages -Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.01700-19
Keywords
PFM-1; Pseudomonas fluorescens; metallo-beta-lactamase
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Funding
- Federal Food Safety and Veterinary Office (FSVO) [1.15.07, 1.15.08]
- Swiss National Science Foundation [FNS-31003A_163432]
- University of Fribourg
- Institute of Veterinary Bacteriology, University of Bern, Switzerland
- European Union [675412]
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A carbapenem-resistant Pseudomonas synxantha isolate recovered from chicken meat produced the novel carbapenemase PFM-1. That subclass B2 metallo-beta-lactamase shared 71% amino acid identity with beta-lactamase Sfh-1 from Serratia fonticola. The bla(PFM-1) gene was chromosomally located and likely acquired. Variants of PFM-1 sharing 90% to 92% amino acid identity were identified in bacterial species belonging to the Pseudomonas fluorescens complex, including Pseudomonas libanensis (PFM-2) and Pseudomonas fluorescens (PFM-3), highlighting that these species constitute reservoirs of PFM-like encoding genes.
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