Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 64, Issue 2, Pages -Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.01885-19
Keywords
Staphylococcus aureus; MRSA; exebacase; CF-301; lysin; synergy; direct lytic agent
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In vitro synergy between an antimicrobial protein lysin (cell wall hydrolase) called exebacase and each of 12 different antibiotics was examined against Staphylococcus aureus isolates using a nonstandard medium approved for exebacase susceptibility testing by the Clinical and Laboratory Standards Institute. In the check-erboard assay format, fractional inhibitory concentration index values of <= 0.5, consistent with synergy, were observed for the majority of interactions tested. Synergy was further confirmed in time-kill assays.
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