Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 58, Issue 50, Pages 18207-18211Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201909870
Keywords
antitumor agents; azobenzene; DNA nanotechnology; drug delivery; upconversion nanoparticles
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Funding
- National Natural Science Foundation of China [21635005, 21605083, 21827812, 21890741, 21771103, 21974064]
- Natural Science Foundation of Jiangsu Province [BK 20160644, BK 20160639]
- State Key Laboratory of Analytical Chemistry for Life Science [5431ZZXM1806]
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Stimulus-responsive drug release possesses considerable significance in cancer therapy. This work reports an upconversion-luminescence-fueled DNA-azobenzene nanopump for rapid and efficient drug release. The nanopump is constructed by assembling the azobenzene-functionalized DNA strands on upconversion nanoparticles (UCNPs). Doxorubicin (DOX) is loaded in the nanopump by intercalation in the DNA helix. Under NIR light, the UCNPs emit both UV and visible photons to fuel the continuous photoisomerization of azo, which acts as an impeller pump to trigger cyclic DNA hybridization and dehybridization for controllable DOX release. In a relatively short period, this system demonstrates 86.7 % DOX release. By assembling HIV-1 TAT peptide and hyaluronic acid on the system, targeting of the cancer-cell nucleus is achieved for perinuclear aggregation of DOX and enhanced anticancer therapy. This highly effective drug delivery nanopump could contribute to chemotherapy development.
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