Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 58, Issue 52, Pages 18981-18986Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201909416
Keywords
graphene oxide; lanthanides; luminescent nanoprobes; NIR-II bioimaging; tumor targeting
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Funding
- Strategic Priority Research Program of the CAS [XDB20000000]
- Chinese Government [2017YFE0132300]
- NSFC [81572944, 21771185, U1505221, 21804134]
- CAS/SAFEA International Partnership Program for Creative Research Teams
- Natural Science Foundation of Fujian Province [2017I0018, 2019J05157]
- China Postdoctoral Science Foundation [2017LH017, 2018M630735]
- Australian Government [2017YFE0132300]
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The synthesis of hydrophilic lanthanide-doped nanocrystals (Ln(3+)-NCs) with molecular recognition ability for bioimaging currently remains a challenge. Herein, we present an effective strategy to circumvent this bottleneck by encapsulating Ln(3+)-NCs in graphene oxide (NCs@GO). Monodisperse NCs@GO was prepared by optimizing GO size and core-shell structure of NaYF4:Yb,Er@NaYF4, thus combining the intense visible/near-infrared II (NIR-II) luminescence of NCs and the unique surface properties and biomedical functions of GO. Such nanostructures not only feature broad solvent dispersibility, efficient cell uptake, and excellent biocompatibility but also enable further modifications with various agents such as DNA, proteins, or nanoparticles without tedious procedures. Moreover, we demonstrate in proof-of-concept experiments that NCs@GO can realize simultaneous intracellular tracking and microRNA-21 visualization, as well as highly sensitive in vivo tumor-targeted NIR-II imaging at 1525 nm.
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