Porous CuxCoyS Supraparticles for In Vivo Telomerase Imaging and Reactive Oxygen Species Generation

In this study, we successfully synthesized CuxCoyS supraparticles (SPs) on the nanoscale featuring multiple pores inside and strong absorption from 400 to 900 nm. Porous CuxCoyS SPs produced the highest reactive oxygen species (ROS) yield (1.39) when illuminated with near-infrared (NIR) light. Furthermore, we demonstrated that CuxCoyS SPs could be used to identify cancer cells through intracellular telomerase-responsive fluorescence (FL) imaging in living cells. Because the CuxCoyS SPs were associated with telomerase-responsive bioimaging and high ROS production, they can be efficiently used in the diagnosis and therapy of tumors with high selectivity and excellent therapeutic effects in vivo. This study provides a new vision for the creation of multifunctional SPs, which can be used as cellular sensors and control tools for pathologies across a broad range of biological systems.