Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 59, Issue 1, Pages 247-252Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201911803
Keywords
bioimaging; fluorescent probes; peroxynitrite; second near-infrared window; traumatic brain injury
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Funding
- National Key Research and Development Program of China [2016YFA0101503, 2017YFA0205503]
- National Natural Science Foundation of China [21671198, 21425103, 21501192, 21934007]
- Chinese Academy of Sciences [XDB32030200, 121E32KYSB20180021, ZDBS-LY-SLH021]
- Natural Science Foundation of Jiangsu Province [BK20170066, BE2016682]
- Youth Innovation Promotion Association of Chinese Academy of Sciences
- CAS Key Laboratory of Nano-Bio Interface [18NBI01]
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Traumatic brain injury (TBI) is one of the most dangerous acute diseases resulting in high morbidity and mortality. Current methods remain limited with respect to early diagnosis and real-time feedback on the pathological process. Herein, a targeted activatable fluorescent nanoprobe (V&A@Ag2S) in the second near-infrared window (NIR-II) is presented for in vivo optical imaging of TBI. Initially, the fluorescence of V&A@Ag2S is turned off owing to energy transfer from Ag2S to the A1094 chromophore. Upon intravenous injection, V&A@Ag2S quickly accumulates in the inflamed vascular endothelium of TBI based on VCAM1-mediated endocytosis, after which the nanoprobe achieves rapid recovery of the NIR-II fluorescence of Ag2S quantum dots (QDs) owing to the bleaching of A1094 by the prodromal biomarker of TBI, peroxynitrite (ONOO-). The nanoprobe offers high specificity, rapid response, and high sensitivity toward ONOO-, providing a convenient approach for in vivo early real-time assessment of TBI.
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