Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 58, Issue 43, Pages 15390-15395Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201905687
Keywords
immunomodulation; innate immunity; lipid amphiphiles; lymph nodes; polymers
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Funding
- DFG [SFB 1066-B4]
- Fonds der Chemischen Industrie (Liebig Program)
- FWO Flanders
- Kom Op Tegen Kanker
- Ghent University
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Uncontrolled systemic inflammatory immune triggering has hampered the clinical translation of several classes of small-molecule immunomodulators, such as imidazoquinoline TLR7/8 agonists for vaccine design and cancer immunotherapy. By taking advantage of the inherent serum-protein-binding property of lipid motifs and their tendency to accumulate in lymphoid tissue, we designed amphiphilic lipid-polymer conjugates that suppress systemic inflammation but provoke potent lymph-node immune activation. This work provides a rational basis for the design of lipid-polymer amphiphiles for optimized lymphoid targeting.
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