Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 59, Issue 8, Pages 3063-3068Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201913023
Keywords
green chemistry; O-dealkylation; C-dealkylation; renewable resources; bond cleavage
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Funding
- Research Foundation Flanders (FWO) (WOG)
- Research Foundation Flanders (FWO) (BioFact Excellence of Science project) [30902231]
- UAntwerp (BOF)
- Research Board of UGent
- VLAIO/Catalisti (ARBOREF)
- BIO-HarT project
- Hercules
- Francqui Foundation
- FWO
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An efficient conversion of biorenewable ferulic acid into bio-catechol has been developed. The transformation comprises two consecutive defunctionalizations of the substrate, that is, C-O (demethylation) and C-C (de-2-carboxyvinylation) bond cleavage, occurring in one step. The process only requires heating of ferulic acid with HCl (or H2SO4) as catalyst in pressurized hot water (250 degrees C, 50 bar N-2). The versatility is shown on a variety of other (biorenewable) substrates yielding up to 84% di-(catechol, resorcinol, hydroquinone) and trihydroxybenzenes (pyrogallol, hydroxyquinol), in most cases just requiring simple extraction as work-up.
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