Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 59, Issue 6, Pages 2375-2379Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201911012
Keywords
dicarbofunctionalization; heterocycles; palladium catalysis; quaternary centers; radicals
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Funding
- Deutsche Forschungsgemeinschaft [SFB 858]
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The redox-neutral dicarbofunctionalization of tri- and tetrasubstituted olefins to form a variety of (hetero)cyclic compounds under photoinduced palladium catalysis is described. This cascade reaction process was used to couple styrenes or acryl amides with a broad range of highly decorated olefins tethered to aryl or alkyl bromides (>50 examples). This procedure enables one or two contiguous all-carbon quaternary centers to be formed in a single step. The products could be readily diversified and applied in the synthesis of a bioactive oxindole analogue.
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