Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 59, Issue 18, Pages 6964-6974Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201910767
Keywords
C-C bond activation; cyclobutanone; desymmetrization; quaternary stereocenters
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Funding
- Westfalische Wilhelms-Universitat Munster
- Fonds der chemischen Industrie
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Cyclobutanones hold a privileged role in enantioselective desymmetrization because their inherent ring strain allows for a variety of unusual reactions to occur. Current strategies include alpha-functionalization, rearrangement, and C-C bond activation to directly convert cyclobutanones into a wide range of enantiomerically enriched compounds, including many biologically significant scaffolds. This Minireview provides an overview of state-of-the-art methods that generate complexity from prochiral cyclobutanones in a single operation.
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